Objectives
Cyclin A1 regulates cell cycle activity and proliferation in somatic and germ-line cells.Its expression increases in G1/S phase and reaches a maximum in G2 and M phases.Altered cyclin A1 expression might contribute to clinical symptoms in facioscapulohumeral muscular dystrophy (FSHD).Effect of slaughter age and feeding system on the neutral and polar lipid composition of horse meat
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Methods
Muscle biopsies were taken from the Vastus lateralis muscle for cDNA microarray, RT-PCR, immunohistochemistry and Western blot analyses to assess RNA and protein expression of cyclin A1 in human muscle cell lines and muscle tissue.Muscle fibers diameter was calculated on cryosections to test for hypertrophy.Results
cDNA microarray data showed specifically elevated cyclin A1 levels in FSHD vs.Essential Preventive Automobile Maintenance during a Pandemic
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other muscular disorders such as caveolinopathy, dysferlinopathy, four and a half LIM domains protein 1 deficiency and healthy controls.Data could be confirmed with RT-PCR and Western blot analysis showing up-regulated cyclin A1 levels also at protein level.We found also clear signs of hypertrophy within the Vastus lateralis muscle in FSHD-1 patients.